Excel Saga is the anime that I immediately think of when somebody says "anime comedy". It could've been FLCL, which I think is better, but FLCL isn't as gut-bustingly hilarious, so much as it is contemplative with a little zaniness baked in. Excel Saga is pure comedy, through and through, and I recall the hype around it on the original Otaku Revolution message board. I didn't see it until ADV licensed it, and I still have the DVD singles that I collected over time. Excel Saga may not be up there among my top 20 anime, but it's always a treat to revisit.